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Sculptra Injections

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What Is Sculptra?
Sculptra is poly-l-lactic acid, a cross-linked lactic acid product which is injected into the dermis to trigger collagen production.  Sculptra is a semi-permanent product designed to create volume and thicken the skin via natural collagen formation and lasts about 18 months.

Sculptra Aesthetic® is FDA approved for cosmetic applications for the nasolabial folds and for other deep dermal wrinkles.  It is also used for cheek volume and along the jaw for augmentation.  It should not be used in the lips, and in thin-skinned areas like under the eyes (although I had gotten it there during clinicals).

Sculptra was originally approved only for patients with lipoatrophy, which is the loss of facial fat/volume from medications and disorders such as those for HIV.  Lipoatrophy is also known as facial wasting and can cause a gaunt, unhealthy look.  However, it was used off-label cosmetically.  Now that Sculptra Aesthetic® is FDA approved for cosmetic applications, patients can readily receive injections from their plastic surgeon or dermatologist.

How Does Sculptra Work?
Sculptra is not a filler, but rather a catalyst.  When Sculptra is injected into your dermis, it creates a low-grade inflammatory response which triggers collagen formation.  The collagen formation is a direct reaction from the irritation caused by the product.   

When you first have the product injected, you will feel that you have volume, therefore improvement. This is, in fact, the saline carrier Sculptra is diluted with.  You will have no true, discernible volume gain for at least 3 weeks, but more than likely closer to 6.  Your swelling will abate and the waiting game will begin.  The product is eventually metabolized by your body, gradually lessening the inflammation over a span of about 2 years.  Your own collagen also gradually dissipates with natural aging and metabolism, hence lessening the volume and result.

Preparing For Your Sculptra Treatment 
You should refrain from any irritating topical medications or products (such as tretinoin [Retin A], TCA, glycolics, lactic acid peels, etc. before your treatment.  You should also cease consuming aspirin and vitamin E for 2 weeks before your treatment.  This will assist in lessening your chances of bleeding and bruising.  If you take Coumadin you should more than likely continue taking your meds as ceasing to do so can be life threatening.  Just be sure to let your physician know.

What To Expect At Your Sculptra Consultation
Your surgeon or dermatologist will examine your skin thickness and receive a complete medical history to determine the state of your health.  You should have no immune disorders and only healthy individuals should receive Sculptra Aesthetic® injections. Your doctor will also explain to you what to expect in the weeks and months ahead, as well as inform you of the possible complications and risks of Sculptra Aesthetic® injections.  If your doctor feels that Sculptra Aesthetic® is right for you, you might have your treatment that same day.

How Sculptra Treatments Are Performed
Sculptra is reconstituted at least 30 minutes before your treatment, although 2 hours is better.  It is diluted with usually 4 to 5 cc of sterile saline per vial/bottle and sometimes Lidocaine.  Although I have received regional anesthesia (nerve blocks) instead of having Lidocaine included in the suspension.  Your doctor will sometimes mark the area you will be having treated.  You are then given the anesthetic and after the anesthetic has taken effect your doctor will then begin your injections.  The injections are given in a cross-hatch method and the area is then massaged to evenly distribute the product.  The swelling is commonly from the saline and subsides in about 4 hours. Any other swelling is normally very slight, as you can see from the photos the next day (below).

I had Sculptra injected under my eyes November 11, 2004, and then to my under eyes, nasolabials and cheeks February 9, 2005.  I will use my photos from November 11, 2004 to give you an idea of what to expect during your treatment.   I also had excision of Radiance FN (Radiesse) from the lower lip right after my Sculptra injection.  This is why you will note the sutures and swelling of my lips in the after photos.  You can see the blanching of the Radiesse and nodules which are clearly visible in the photos directly below.

Injections to under eyes

injections to cheeks

   

injections to nasolabials

massage

swelling and redness about 30 minutes after procedure

The Road To Recovery 
Many physicians instruct you to massage your treatment area to hinder the formation of nodules/granulomas (painful lumps and bumps).  I was personally instructed to do so a few times a day and to take note of any irregularities.  You will have very slight swelling at first but it should subside in under a week.  Although you may like the swelling as it smoothes out wrinkles.  You may feel that you have had no improvement once the swelling goes down, but please remember that the improvement with Sculptra happens over the next few weeks and months not immediately.  Your collagen needs a chance to form and peaks around the 3 month mark.

1 Day Post (the next day) - Also had Radiesse Removal from the Lips

Treatments are repeated approximately every 6 weeks for 3 to 4 treatments.  You should begin to notice your first results at about 6 weeks.  If you are going to form nodules, they commonly form within 3 to 6 weeks and should be reported to your doctor.  Nodules that can be felt, but not seen may occur.  Read my Sculptra Journal.

I had my second treatment 3 months later.  The collagen had formed in the areas where it was injected but where it was not, you could see little indentations.  Hence the second treatment.  Read my Second Sculptra Journal with a photo of the slightly perceptible nodule under the eye and end results. 

Risks & Complications Of Sculptra
The most common complication of Sculptra is palpable nodules. 
I had a slightly visible nodule for about 7 to 9 months.  It was more easily felt than seen.  Other complications or risks include, blanching of the skin if injected too superficially (white areas seen under the skin).  I had blanching at the nodule only.   I did have thickening of the dermis which caused the darkness under my eyes and the vascularity to be less visible.  Again, Sculptra is not recommended for under the eyes anymore. 

Rare complications include hematoma, seroma, infection, necrosis, hyperpigmentation from bruising, and , prolonged abnormal inflammation.

The Average Prices Of Sculptra
The average cost of Sculptra is  approximately $300 to $500 per cc, and averages $1,500 per treatment which may include about 4cc.   The costs varies significantly so be sure to ask around.  Although don't base your doctor of choice on price alone.  Sculptra must be injected by someone with experience as complications are difficult to correct.

Frequently Asked Questions About Sculptra (Interview with Dr. Gail Humble)

Q. How long do the results from Sculptra last?
A. Your results last up to 24 months.

Q. How many rounds has the average patient without HIV needed for standard cheek augmentation? 
A. Between 2-3 treatments.

Q. What is the % of incidence of serious lumping requiring treatment?
A. 1 to 10% depending on what study.  54% spontaneously resolve the others respond to the below treatments.  Honestly with the new more dilute injection, even before, I have only seen 2 in four years in my patients.

Q. If there are lumps, what types of treatments are available?
A. Most of the time they resolve on their own, but if not you can do steroid injections, physically break it up (if they are new) with a needle or 5FU injections.

Q. How many cc of product is contained in one vial of Sculptra once reconstituted?  
A. 5cc

Q. Is it true it must be reconstituted several hours (how many) beforehand and is only good for 72 hours? 
A. Sculptra should be mixed AT LEAST 30 min prior to procedure.  Once mixed it is good for 72 hours. 

Q. About how many ppm (or whatever %) of Sculptra to saline is commonly used.
A. We mix it with 4cc sterile H2O and 1cc of Lidocaine

Q. How much do you charge per round of Sculptra?  
A. There is a $500 administration fee and $100/cc of Sculptra per visit.  The cost for the product is the same that we have to pay.  There is no up-charge.

Source: Gail Humble, M.D.

Dr. Jonathan Hoenig Answers a Few Questions About Sculptra

Q. Does Dr. Hoenig use Sculptra in the nasolabial folds?

A. Dr Hoenig likes to inject Juvederm in the lips and the nasolabial folds.

He uses Sculptra as an alternative to fat transfer - when someone needs a lot of volume in the cheeks but doesn't want surgery, recovery time, or doesn't have fat to harvest.

Dr. Hoenig only uses Restylane under the eyes.  In his experience, Juvederm seems to attract too much fluid and gets too puffy.  He doesn't use Sculptra under the eyes because you can't control how much collagen will build up around the Sculptra and work around the eyes needs to be very precise.  Also, with Radiesse and Sculptra you can get bumps which can't be dissolved like they can with hyaluronic acid fillers.

Sculptra, in his opinion, is not good for detailed work (like around the eyes) and definitely not in the lips.  It's good as a large volume filler when 5-25 or more cc's volume are needed.  He has devised his own dilution method to avoid lumps and bumps.

As an aside, he did Sculptra on me for the cheeks and jaw a few years ago.

One drawback is that you have to wait 4-6 weeks before you start to notice any results.

Danya Hoenig, P.A.

My Personal Opinion: Comparing Sculptra, Fat Grafting, Juvederm and Radiesse
I have had Sculptra, Fat Grafting (Twice), Juvederm, Restylane and Radiesse to my cheek area and I must say that overall, I prefer the convenience and immediate satisfaction that I got from Radiesse, as well as the longevity.

  • Sculptra:  In retrospect, I DO like how it thickened the dermis, filled out lines and decreased the visibility of the under eye vascularity.  It actually made the skin thicker so that the veins did not show through as well.  Unfortunately, Sculptra may not be the best for the under eye area.  I feel that the benefits versus the risk of palpable nodules in the under eye area is not worth it considering the other products and procedures which are out there now.  I feel that it is nice for cheeks and the buccal area (lower, sunken in area of the face) however, but I am very impatient and 6 weeks per treatment with gradual augmentation just isn't what I want out of a product.  This is just my personal experience. 

  • Fat Grafting: I feel that fat grafting, although nice, smooth and natural (and I LOVED the slight, post-operative swelling I had even after 6 weeks, it just doesn't last as long.  Plus fat transfer requires a donor site and also I felt that I did have scar tissue from the placement of the fat.  I do realize that today, with the use of your own stem cells, the fat graft can have a better chance of survival so this is promising for future endeavors.

  • Juvederm:  I like Juvederm in the cheeks and nasolabials.   I have had Restylane in these areas as well, and feel that hyaluronic acid fillers are great in that they are soft and reversible.  However, their temporary nature is the one true drawback.  But this is also its benefit if you think about it.  You can't have it both ways.  I feel that Juvederm lasts longer in the cheeks and nasolabials than Restylane but is not best for under the eyes like Restylane is.  Although the Tyndall effect (bluish cast under the eyes, Tyndall scattering) after injection is sometimes a problem.

  • Radiesse: I do prefer Radiesse for the cheek area (not NOT for the under eye or lips).  Reason being it is immediate and affordable and lasts just the right amount of time.  Your face can change as you age and I feel that although 4 months for Juvederm is too short, 2 years for Radiesse is just right.  A lot can change in 2 years, and the dissipation is quite gradual.  Nodules are possible, as I have found out, but injector skill is paramount in the overall end result.

Product and Procedure Comparison Based Upon My Own Experience

Product  Mechanism  FDA approved Discomfort Longevity Cost Would get again?
Sculptra

Catalyst

Y suggest anesthetic 18 months $900 Maybe
Fat Grafting x 2

Filler

N/A suggest sedation 6 months $2,500 Maybe
Restylane Filler Y suggest anesthetic 5 months $400 Y
Juvederm Filler Y suggest anesthetic 6 months $500 Y
Radiesse Temporary Filler  Catalyst Y suggest anesthetic 14 months thus far $1,200 Y

References 
Interview with Gail Humble, M.D.
Interview with Dr. Jonathan Hoenig
Personal Treatment Experiences

 

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